Influenza virus infection of newborn rats: Virulence of recombinant strains prepared from a cold-adapted, attenuated parent
Identifieur interne : 002943 ( Main/Exploration ); précédent : 002942; suivant : 002944Influenza virus infection of newborn rats: Virulence of recombinant strains prepared from a cold-adapted, attenuated parent
Auteurs : M. I. A. Mahmud [Royaume-Uni] ; H. F. Maassab [États-Unis] ; R. Jennings [Royaume-Uni] ; C. W. Potter [Royaume-Uni]Source :
- Archives of Virology [ 0304-8608 ] ; 1979-09-01.
English descriptors
- Teeft :
- Attenuated, Bacteraemia, Bacterial infection, Baeteraemia, Clone, High titres, Human virulence, Infant rats, Infant rats inoculated, Infection, Influenza, Influenza virus, Influenza virus infection, Influenza virus strains, Influenza viruses, Inoculated, Inoculation, Lower titres, Lung extracts, Meningitis, Newborn rats, Organ cultures, Peak titres, Previous studies, Rat, Recombinant, Recombinant viruses, Replication, Titre, Turbinate, Turbinate extracts, Virulence, Virulent, Virus, Virus infection, Virus replication, Virus strains, Virus titres, Virus virulence.
Abstract
Summary: Infant rats were infected with one of a series of influenza A viruses. The growth of viruses in the turbinates or lungs, and the ability of virus infection to potentiate a subsequent bacterial infection by Haemophilus influenzae (HIb), were measured. The three virus strains known to be virulent for man grew to relatively high titres-of 105.0–106.8 EBID50/ml in the turbinates of infant rats at 48 hours post-infection, and virus infection enhanced subsequent systemic infection following intranasal inoculation of rats with HIb. In contrast, influenza virus A/Ann Arbor/6/60—P17 and the three recombinant viruses prepared from this strain, all of which are attenuated for man, replicated to significantly lower titres of 102.6–104.1 EBID50/ml in infant rats turbinates, and failed to promote systemic infection by HIb to the same degree. The results, together with those of previous studies, suggest that the behaviour of influenza viruses in infant rats may be an indication for virus virulence for man, and thus provide a test which could facilitate the development of live, attenuated virus vaccines.
Url:
DOI: 10.1007/BF01318055
Affiliations:
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The growth of viruses in the turbinates or lungs, and the ability of virus infection to potentiate a subsequent bacterial infection by Haemophilus influenzae (HIb), were measured. The three virus strains known to be virulent for man grew to relatively high titres-of 105.0–106.8 EBID50/ml in the turbinates of infant rats at 48 hours post-infection, and virus infection enhanced subsequent systemic infection following intranasal inoculation of rats with HIb. In contrast, influenza virus A/Ann Arbor/6/60—P17 and the three recombinant viruses prepared from this strain, all of which are attenuated for man, replicated to significantly lower titres of 102.6–104.1 EBID50/ml in infant rats turbinates, and failed to promote systemic infection by HIb to the same degree. The results, together with those of previous studies, suggest that the behaviour of influenza viruses in infant rats may be an indication for virus virulence for man, and thus provide a test which could facilitate the development of live, attenuated virus vaccines.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Michigan</li></region></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Mahmud, M I A" sort="Mahmud, M I A" uniqKey="Mahmud M" first="M. I. A." last="Mahmud">M. I. A. Mahmud</name></region><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R." last="Jennings">R. Jennings</name><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C. W." last="Potter">C. W. Potter</name></country><country name="États-Unis"><region name="Michigan"><name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H. F." last="Maassab">H. F. Maassab</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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